A Prospective Multicenter Study of the Chinese Scoring System for Hepatitis B Liver Failure

Frontiers in Medicine

Ren Wan-hua¹  Wang Kai²  Wu Zhe-bin³  Ke Wei-min³  Zheng Yu-bao³  Peng Liang³  Gao Zhi-liang³  Lin Bing-liang³  Zhang Xin-xin⁴  Yan Xue-bin⁵  Chen Zhi⁶  Tan De-ming⁷ 

[1] Department of Infectious Diseases, Shandong Provincial Hospital, Jinan, China;Department of Infectious Diseases, Shandong University Qilu Hospital, Jinan, China;Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, China;The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China;The First Affiliated Hospital of Zhejiang University, Hangzhou, China;Xiangya Hospital, Central South University, Changsha, China;

关键词: hepatitis B;    liver failure;    scoring system;    end-stage liver disease model;    assessing;   

DOI  :  10.3389/fmed.2021.751807

来源: DOAJ

【 摘 要 】

Objective: To evaluate the clinical utility of a Chinese scoring system for hepatitis B liver failure in a prospective and multicenter study.Methods: Clinical data for 1,143 patients with hepatitis B liver failure who had been followed up for a minimum of 6 months were collected from seven liver disease centers across China. The disease severity and prognosis for the patients were predicted using the Chinese scoring system and compared to those predicted with the model for end-stage liver disease (MELD) score, MELD-Na score, and Child-Turcotte-Pugh (CTP) score.Results: The Chinese scoring system was more effective at predicting the outcomes of survival and mortality than the MELD score. In the peak disease stage, the area under the receiver operating characteristic curve for the Chinese scoring system was 0.954, significantly higher than that (0.896) for the MELD scoring system (P < 0.001). The positive prediction at 30, 90, and 180 days with the Chinese scoring system was 0.764 (95% CI: 0.714–0.808), 0.731 (95% CI: 0.694–0.769), and 0.724 (95% CI: 0.679–0.765), also significantly higher than that with the MELD, MELD-Na, and CTP scores (P < 0.001). In addition, the Chinese scoring system was superior to the MELD, MELD-Na, and CTP scores (P < 0.001) at predicting the prognosis of patients with hepatitis B liver failure at both 30 and 180 days.Conclusion: The Chinese scoring system demonstrated superior performance to the three established scoring systems in assessing the severity and outcomes of hepatitis B liver failure in this cohort.

【 授权许可】

Unknown