The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment

Frontiers in Immunology

Evren Alici¹  Maria Karvouni²  Katharina Helene Susek²  Andreas Lundqvist³ 

[1]Cell Therapy Institute, Nova Southeastern University, Fort Lauderdale, FL, United States

[2]Department of Medicine, Karolinska Institutet (KI), Solna, Sweden

[3]Department of Oncology-Pathology, Karolinska Institutet (KI), Solna, Sweden

关键词: chemokines;    cancer immunotherapy;    metastasis;    NK cells;    T cells;    myeloid cells;   

DOI  :  10.3389/fimmu.2018.02159

来源: DOAJ

【 摘 要 】

Chemokines govern leukocyte migration by attracting cells that express their cognate ligands. Many cancer types show altered chemokine secretion profiles, favoring the recruitment of pro-tumorigenic immune cells and preventing the accumulation of anti-tumorigenic effector cells. This can ultimately result in cancer immune evasion. The manipulation of chemokine and chemokine-receptor signaling can reshape the immunological phenotypes within the tumor microenvironment in order to increase the therapeutic efficacy of cancer immunotherapy. Here we discuss the three chemokine-chemokine receptor axes, CXCR1/2–CXCL1-3/5-8, CXCR3–CXCL9/10/11, and CXCR4-CXCL12 and their role on pro-tumorigenic immune cells and anti-tumorigenic effector cells in solid tumors. In particular, we summarize current strategies to target these axes and discuss their potential use in treatment approaches.

【 授权许可】

Unknown