Bioactive skin-mimicking hydrogel band-aids for diabetic wound healing and infectious skin incision treatment

Bioactive Materials

Yuxuan Yang¹  Shuang Wang¹  Xiaodan Zhao¹  Qiang Zhang²  Xingxing Chen²  Yilong Cheng²  Jing Yu²  Ruyue Wang²  Mengyuan Zhang²  Yanfeng Zhang² 

[1] Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710049, China;School of Chemistry, Xi'an Jiaotong University, Xi'an, 710049, China;

关键词: Hydrogel;    Tannic acid;    Wound dressing;    Chronic diabetic wound;    Hydrogen bonding;   

DOI  :  

来源: DOAJ

【 摘 要 】

The treatment of diabetic chronic wounds remains a global challenge due to the up-regulated inflammation response, oxidant stress, and persistent infection during healing process. Developing wound dressing materials with ideal biocompatibility, adequate mechanical strength, considerable under-water adhesion, sufficient anti-inflammation, antioxidant, and antibacterial properties is on-demand for clinical applications. In this study, we developed a bioactive skin-mimicking hydrogel band-aid through the combination of tannic acid (TA) and imidazolidinyl urea reinforced polyurethane (PMI) (TAP hydrogel) and explored its potentials in various medical applications, including hemostasis, normal skin incision, full-thickness skin wounds, and bacterial-infection skin incision on diabetic mice. TA was loaded into PMI hydrogel network to enhance the mechanical properties of TAP hydrogels through multiple non-covalent interactions (break strength: 0.28–0.64 MPa; elongation at break: 650–930%), which could resist the local stress and maintain the structural integrity of wound dressings during applications. Moreover, owing to the promising moisture-resistant adhesiveness and organ hemostasis, outstanding anti-inflammation, antibacterial, and antioxidant properties, TAP hydrogels could efficiently promote the recovery of skin incision and defects on diabetic mice. To further simulate the practical situation and explore the potential in clinical application, we also verified the treatment efficiency of TAP hydrogel in S. aureus-infected skin incision model on diabetic mice.

【 授权许可】

Unknown