Obesity induced by estrogen deficiency is associated with hypothalamic inflammation

Biochemistry and Biophysics Reports

Sunggu Yang¹  Jae Geun Kim²  Da Yeon Jeong²  Hye Rim Yang²  Thai Hien Tu² 

[1] Department of Nano-Bioengineering, Incheon National University, Incheon, 22012, South Korea;Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, South Korea;

关键词: Menopause;    Estrogen;    Hypothalamus;    Inflammation;    Microglia;    Obesity;   

DOI  :  

来源: DOAJ

【 摘 要 】

Occurrence of obesity during the postmenopausal period is closely associated with inflammatory processes in multiple peripheral organs that are metabolically active. Hypothalamic inflammation has been recognized as one of the major underlying causes of various metabolic disorders, including obesity. The association between menopause-related obesity and hypothalamic inflammation remains poorly understood. We observed an elevation in hypothalamic inflammation in the ovariectomized mice, which displayed altered metabolic phenotypes and visceral obesity. Furthermore, we confirmed that ovariectomized mice displayed microglial activation accompanied by the upregulation of multiple genes involved in the inflammatory responses in hypothalamic microglia. Collectively, the current findings suggest that hypothalamic inflammation associated with microglial functioning could be a major pathogenic element in disruption of energy homeostasis during the postmenopausal period.

【 授权许可】

Unknown