Dynamic Cerebral Autoregulation Remains Stable During the Daytime (8 a.m. to 8 p.m.) in Healthy Adults

Frontiers in Physiology

Yi Yang¹  Zhen-Ni Guo¹  Wei-tong Guo²  Hongyin Ma²  Jia Liu³ 

[1] Department of Neurology, Clinical Trial and Research Center for Stroke, The First Hospital of Jilin University, Changchun, China;Department of Neurology, The First Hospital of Jilin University, Changchun, China;Institute of Advanced Computing and Digital Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, University Town of Shenzhen, Shenzhen, China;

关键词: dynamic cerebral autoregulation;    blood pressure;    cerebral blood flow;    daily rhythm;    cerebrovascular disease;   

DOI  :  10.3389/fphys.2018.01642

来源: DOAJ

【 摘 要 】

Many functions of the human body possess a daily rhythm, disruptions of which often lead to disease. Dynamic cerebral autoregulation (dCA) stabilizes the cerebral blood flow to prompt normal neural function. However, whether dCA is stable across the day remains unknown. This study aimed to investigate the daily rhythm of dCA. Fifty-one healthy adults (38.294 ± 13.279 years, 40 females) were recruited and received six dCA measurements per individual that were conducted at predefined time points: 8:00, 9:00, 11:00, 14:00, 17:00, and 20:00. Although the blood pressure fluctuated significantly, there was no statistical difference in phase difference and gain (autoregulatory parameters) across the six time points. This study demonstrates that dCA remains stable during the interval from 8 a.m. to 8 p.m. and underscores the importance of stable dCA in maintaining cerebral blood flow and neural function.

【 授权许可】

Unknown