The middle meningeal artery as an alternative route for intra-arterial chemotherapy

Interdisciplinary Neurosurgery

Pascal Jabbour¹  Nohra Chalouhi¹  Stavropoula Tjoumakaris¹  Mario Zanaty¹  Robert H. Rosenwasser¹  Carol L. Shields² 

[1] Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA;Department of Ophthalmology, Thomas Jefferson University Hospital, Philadelphia, PA, USA;

关键词: Retinoblastoma;    Intraarterial chemotherapy;    Ophthalmic artery;    Middle meningeal artery;    Stenosis;   

DOI  :  10.1016/j.inat.2015.02.003

来源: DOAJ

【 摘 要 】

Retinoblastoma is a deadly eye cancer in children, leading to death in 50%–70% of children in undeveloped nations. Unfortunately, this aggressive tumor is the most common intraocular malignancy worldwide. For the last 2 decades, intravenous (IV) chemotherapy has been the mainstay of treatment for retinoblastomas. This route has provided improved control in retinoblastoma, with sparing of the eye and vision in some cases. More recently, intra-arterial chemotherapy (IAC) has become the first line treatment for advanced and refractory retinoblastoma in many centers worldwide. The advances in treatment along with early tumor detection are responsible for the favorable prognosis found in developed nations. IAC classically uses the ophthalmic artery (OA) in attempt to deliver the maximal dose of chemotherapy while minimizing systemic complications. However, direct catheterization of the ophthalmic artery (OA) is not always possible. The purpose of this article is to describe a case where the OA has been thrombosed and an alternative access route using the middle meningeal artery (MMA) was used.

【 授权许可】

Unknown