Adult born olfactory bulb dopaminergic interneurons: molecular determinants and experience-dependent plasticity

Frontiers in Neuroscience

Serena eBovetti¹  Sara eBonzano²  Paolo ePeretto²  Silvia eDe Marchis²  Claudio eGendusa³ 

[1] Italian Institute of Technology;Neuroscience Institute Cavalieri Ottolenghi;University of Turin;

关键词: Dopaminergic Neurons;    Olfactory Bulb;    adult neurogenesis;    Tyrosine hydroxylase (th);    COUP-TFI;    odor enrichment;   

DOI  :  10.3389/fnins.2016.00189

来源: DOAJ

【 摘 要 】

The olfactory bulb (OB) is a highly plastic brain region involved in the early processing of olfactory information. A remarkably feature of the OB circuits in rodents is the constitutive integration of new neurons that takes place during adulthood. Newborn cells in the adult OB are mostly inhibitory interneurons belonging to chemically, morphologically and functionally heterogeneous types. Although there is general agreement that adult neurogenesis in the OB plays a key role in sensory information processing and olfaction-related plasticity, the contribution of each interneuron subtype to such functions is far to be elucidated. Here, we focus on the dopaminergic (DA) interneurons: we highlight recent findings about their morphological features and then describe the molecular factors required for the specification/differentiation and maintenance of the DA phenotype in adult born neurons. We also discuss dynamic changes of the DA interneuron population related to age, environmental stimuli and lesions, and their possible functional implications.

【 授权许可】

Unknown