The Innovative Potential of Statins in Cancer: New Targets for New Therapies

Frontiers in Chemistry

Elisabetta Di Bello¹  Antonello Mai¹  Sergio Valente¹  Clemens Zwergel² 

[1] Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy;Department of Precision Medicine, Luigi Vanvitelli, University of Campania, Naples, Italy;

关键词: cancer;    statins;    drug combination;    target therapy;    mevalonate pathway;    HMG-CoA reductase;   

DOI  :  10.3389/fchem.2020.00516

来源: DOAJ

【 摘 要 】

Numerous and different types of cancers possess the dysregulation of the mevalonate pathway as a common feature. Statins, traditionally applied in cardiovascular diseases to reduce lipid levels, subsequently have been discovered to exhibit anti-cancer activities also. Indeed, statins influence proliferation, migration, and survival of cancer cells by regulating crucial signaling proteins, such as Rho, Ras, and Rac. Recently, several studies have demonstrated that simvastatin, fluvastatin, and lovastatin are implicated in different pathways that enhance the survival time of patients with cancer under treatment in combination with antineoplastic agents. In this minireview, we present an overview of the most important studies conducted regarding the use of statins in cancer therapy up to date.

【 授权许可】

Unknown