The Value of Platelet-to-Lymphocyte Ratio as a Prognostic Marker in Cholangiocarcinoma: A Systematic Review and Meta-Analysis

Cancers

Ulf P. Neumann¹  Zoltan Czigany¹  Dong Liu¹  Sven A. Lang¹  Lara R. Heij¹  Tom F. Ulmer¹  Jan Bednarsch¹  Stefan A. W. Bouwense²  Ronald van Dam² 

[1] Department of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, Germany;Department of Surgery, Maastricht University Medical Center (MUMC), 6229 HX Maastricht, The Netherlands;

关键词: cholangiocarcinoma (CCA);    platelet-to-lymphocyte ratio (PLR);    oncological prognosis;    systematic review;    meta-analysis;   

DOI  :  10.3390/cancers14020438

来源: DOAJ

【 摘 要 】

The platelet-to-lymphocyte ratio (PLR), an inflammatory parameter, has shown prognostic value in several malignancies. The aim of this meta-analysis was to determine the impact of pretreatment PLR on the oncological outcome in patients with cholangiocarcinoma (CCA). A systematic literature search has been carried out in the PubMed and Google Scholar databases for pertinent papers published between January 2000 and August 2021. Within a random-effects model, the pooled hazard ratio (HR) and 95% confidence interval (CI) were calculated to investigate the relationships among the PLR, overall survival (OS), and disease-free survival (DFS). Subgroup analysis, sensitivity analysis, and publication bias were also conducted to further evaluate the relationship. A total of 20 articles comprising 5429 patients were included in this meta-analysis. Overall, the pooled outcomes revealed that a high PLR before treatment is associated with impaired OS (HR = 1.14; 95% CI = 1.06–1.24; p < 0.01) and DFS (HR = 1.57; 95% CI = 1.19–2.07; p < 0.01). Subgroup analysis revealed that this association is not influenced by the treatment modality (surgical vs. non-surgical), PLR cut-off values, or sample size of the included studies. An elevated pretreatment PLR is prognostic for the OS and DFS of CCA patients. More high-quality studies are required to investigate the pathophysiological basis of the observation and the prognostic value of the PLR in clinical management as well as for patient selection.

【 授权许可】

Unknown