Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model

Materials

Jan Pinc¹  Jaroslav Čapek¹  Jiří Kubásek²  Jaroslava Dušková³  Radka Vrbová⁴  Eitan Brizman⁴  Milan Drahoš⁴  Martin Bartoš⁴  Dan Ulmann⁴  Tereza Ulmannová⁴  René Foltán⁴  Karel Klíma⁴  Michal Španko⁴  Michal Beňo⁴ 

[1] Department of Functional Materials, FZU The Institute of Physics of the Czech Academy of Sciences, Na Slovance 1999/2, 182 21 Prague, Czech Republic;Department of Metals and Corrosion Engineering, University of Chemistry and Technology, Technická 6, 166 28 Prague, Czech Republic;Department of Pathology, First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic;Department of Stomatology—Maxillofacial Surgery, General Teaching Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic;

关键词: bioabsorbable metals;    in-vivo biocompatibility;    magnesium;    zinc;    strontium;    toxicity;   

DOI  :  10.3390/ma14123271

来源: DOAJ

【 摘 要 】

In this pilot study, we investigated the biocompatibility and degradation rate of an extruded Zn–0.8Mg–0.2Sr (wt.%) alloy on a rabbit model. An alloy screw was implanted into one of the tibiae of New Zealand White rabbits. After 120 days, the animals were euthanized. Evaluation included clinical assessment, microCT, histological examination of implants, analyses of the adjacent bone, and assessment of zinc, magnesium, and strontium in vital organs (liver, kidneys, brain). The bone sections with the implanted screw were examined via scanning electron microscopy and energy dispersive spectroscopy (SEM-EDS). This method showed that the implant was covered by a thin layer of phosphate-based solid corrosion products with a thickness ranging between 4 and 5 µm. Only negligible changes of the implant volume and area were observed. The degradation was not connected with gas evolution. The screws were fibrointegrated, partially osseointegrated histologically. We observed no inflammatory reaction or bone resorption. Periosteal apposition and formation of new bone with a regular structure were frequently observed near the implant surface. The histological evaluation of the liver, kidneys, and brain showed no toxic changes. The levels of Zn, Mg, and Sr after 120 days in the liver, kidneys, and brain did not exceed the reference values for these elements. The alloy was safe, biocompatible, and well-tolerated.

【 授权许可】

Unknown