Angioedema and Fatty Acids

International Journal of Molecular Sciences

Yu Sawada¹  Hitomi Sugino¹  Motonobu Nakamura¹  Akane Wada¹ 

[1] Department of Dermatology, Faculty of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanisi-Ku, Kitakyushu, Fukuoka 807-8555, Japan;

关键词: angioedema;    fatty acids;    hereditary angioedema;   

DOI  :  10.3390/ijms22169000

来源: DOAJ

【 摘 要 】

Angioedema is a life-threatening emergency event that is associated with bradykinin and histamine-mediated cascades. Although bradykinin-mediated angioedema currently has specific therapeutic options, angioedema is sometimes intractable with current treatments, especially histamine-mediated angioedema, suggesting that some other mediators might contribute to the development of angioedema. Fatty acids are an essential fuel and cell component, and act as a mediator in physiological and pathological human diseases. Recent updates of studies revealed that these fatty acids are involved in vascular permeability and vasodilation, in addition to bradykinin and histamine-mediated reactions. This review summarizes each fatty acid’s function and the specific receptor signaling responses in blood vessels, and focuses on the possible pathogenetic role of fatty acids in angioedema.

【 授权许可】

Unknown