Different Timing of Prenatal Organophosphate Pesticides Exposure Is Influenced Different Aspects of Infant Developmental Performance

Toxics

Boonsita Suwannakul¹  Ratana Sapbamrer¹  Natrujee Wiwattanadittakul²  Surat Hongsibsong³ 

[1] Department of Community Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthavaroros, Sri Phum Subdistrict, Muang District, Chiang Mai 50200, Thailand;Department of Pediatrics, Faculty of Medicine, Chiang Mai University, 110 Inthavaroros, Sri Phum Subdistrict, Muang District, Chiang Mai 50200, Thailand;Environmental and Occupational Health Sciences and Non Communicable Diseases Center of Excellence, Chiang Mai University, 110 Inthavaroros Road, Sriphum Subdistrict, Muang District, Chiang Mai 50200, Thailand;

关键词: organophosphates;    prenatal exposure;    developmental performance;    infants;    pesticides;   

DOI  :  10.3390/toxics9050099

来源: DOAJ

【 摘 要 】

Organophosphate (OP) pesticides can transfer from mother to fetus via the placenta and amniotic fluid and may affect the development of infants. This study aims to evaluate the associations between maternal OP concentrations collected in the 1st–2nd trimester and the 3rd trimester of pregnancy and the infant developmental performance. The Screening Test of the Bayley Scales of Infants and Toddler Development, Third Edition (BSID–III screening test) was used to assess development performance at 2 and 6 months of age. Multiple regression analysis showed a negative correlation between cognitive performance at 2 months and maternal diethylthiophosphate (DETP) levels in the 1st–2nd trimester (β ± SE = −0.012 ± 0.004, p < 0.05). We also found that expressive communication and fine motor performance at 6 months were negatively associated with maternal diethyldithiophosphate (DEDTP) levels in the 3rd trimester (β ± SE = −0.047 ± 0.016, p < 0.05, and β ± SE = −0.044 ± 0.017, p < 0.05, respectively). These results suggest that maternal ethylated OP concentrations at different timing of exposure during pregnancy may influence different aspects of infant developmental performance.

【 授权许可】

Unknown