Post-malarial anemia in Mozambican children treated with quinine or artesunate: A retrospective observational study

International Journal of Infectious Diseases

Antonio Sitoe¹  Llorenç Quintó²  Gizela Bambo²  Clara Menéndez²  Ana Marta Valente³  Rosauro Varo⁴  Daniel Camprubí⁴  Sozinho Acácio⁴  Eusebio Macete⁴  Alfredo Mayor⁴  Quique Bassat⁴  Jose Muñoz⁴  Pio Vitorino⁵  Lola Madrid⁶  Pedro Aide⁶  Pedro L. Alonso⁶ 

[1] Corresponding author at: Barcelona Institute for Global Health, Carrer Roselló, 132, Sobreátic, 08036, Barcelona, Spain.;ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain;Tropical Medicine, London, UK;Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique;;Department of Infectious Disease Epidemiology, London School of Hygiene &ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain;

关键词: Severe malaria;    Anemia;    Hemolysis;    Artesunate;    Quinine;    African children;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objectives: This retrospective analysis performed in Manhiça, Southern Mozambique, aimed to describe the frequency of post-malarial anemia (measured as a decrease of hematocrit ≥10%) and the need for blood transfusions in children with severe malaria treated with intravenous quinine or parenteral artesunate. Methods: All children <15 years admitted with a parasitologically-confirmed diagnosis of malaria from 1st January 2003 to 31st December 2017, alive at hospital discharge, and with at least one measurement of hematocrit within 28 days after hospital discharge, detected by passive case detection, were included. Results: The overall prevalence of post-malarial anemia observed in the study was 23.13%, with an estimated incidence rate of 288.84 episodes/1,000 children-month at risk in the follow-up period (28 days after discharge). There were no differences between treatment groups, although the study showed a higher association between blood transfusions and artesunate treatment. Conclusions: In this setting, children with severe malaria frequently present a meaningful decrease of hematocrit (>=10%) in the first weeks after their episode, sometimes requiring blood transfusions. Because of the high underlying prevalence of anemia in malaria-endemic settings, all children with severe malaria need to be actively followed up, irrespective of the treatment received.

【 授权许可】

Unknown