Relative Biological Effectiveness of Carbon Ions for Head-and-Neck Squamous Cell Carcinomas According to Human Papillomavirus Status

Journal of Personalized Medicine

Daijiro Kobayashi¹  Yuka Hirota²  Tatsuya Ohno²  Naoto Osu²  Takahiro Oike²  Katsuyuki Shirai³  Atsushi Musha⁴  Hiro Sato⁴  Atsushi Shibata⁵ 

[1] Department of Radiation Oncology, Gunma Prefectural Cancer Center, 617-1, Takahayashi-nishicho, Ota 373-8550, Japan;Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi 371-8511, Japan;Department of Radiology, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi 329-0498, Japan;Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi 371-8511, Japan;Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), 3-39-22, Showa-machi, Maebashi 371-8511, Japan;

关键词: carbon-ion radiotherapy;    head-and-neck tumors;    squamous cell carcinoma;    radiosensitivity;    relative biological effectiveness;   

DOI  :  10.3390/jpm10030071

来源: DOAJ

【 摘 要 】

Carbon-ion radiotherapy (CIRT) has strong antitumor effects and excellent dose conformity. In head-and-neck squamous cell carcinoma (HNSCC), human papillomavirus (HPV) status is a prognostic factor for photon radiotherapy outcomes. However, the effect of HPV status on the sensitivity of HNSCCs to carbon ions remains unclear. Here, we showed that the relative biological effectiveness (RBE) of carbon ions over X-rays was higher in HPV-negative cells than in HSGc-C5 cells, which are used for CIRT dose establishment, whereas the RBE in HPV-positive cells was modest. These data indicate that CIRT is more advantageous in HPV-negative than in HPV-positive HNSCCs.

【 授权许可】

Unknown