Relationship between the geometry patterns of vertebrobasilar artery and atherosclerosis

BMC Neurology

Shi-Wen Wu¹  Yu-Ru Dong¹  Yi Ma¹  Shu Zhang¹  Jin Yu¹  Ming-Li Li²  Wei-Hai Xu²  Shan Gao²  Feng Feng²  Min Lou³ 

[1] Department of Neurology and Radiology, General Hospital of Chinese People’s Armed Police Forces;Department of Neurology and Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences;Department of Neurology, Zhejiang University 2nd Affiliate Hospital;

关键词: Intracranial atherosclerosis;    Vertebrobasilar system;    Geometry;    Plaque;    Magnetic resonance imaging;   

DOI  :  10.1186/s12883-018-1084-6

来源: DOAJ

【 摘 要 】

Abstract Background The plaques at the dorsal or lateral wall of basilar artery (BA) are associated with pontine infarcts. We sought to explore the correlations between vertebrobasilar artery geometry and BA plaque locations. Methods We retrospectively analyzed the imaging and clinical data of 84 patients with BA atherosclerosis. On three-dimensional time-of-flight images, a side to side diameter difference of bilateral vertebral artery (VA) and BA bending were assessed. The vertebrobasilar artery geometry was qualitatively classified into four basic configurations: Walking, Tuning Fork, Dominant-Lambda, and Hypoplasia-Lambda. On high-resolution magnetic resonance imaging, the plaques were categorized based on the involvement of the ventral, dorsal, or lateral sides of BA wall. The relationships between vertebrobasilar artery geometry parameters and plaque locations were analyzed. Results Left VA dominance was identified in 28(33%) patients, and right VA dominance in 22(26%) patients. BA bending were detected in 49 patients. There were no significant correlations between the diameter difference/ratio of VA diameters and plaque locations, or between BA bending and plaque locations. BA plaques were evenly distributed in the vertebrobasilar arteries with Tuning Fork and Dominant-Lambda configurations. In Hypoplasia-Lambda group, however, plaques were more frequently located at the dorsal wall (58.57%) than at the ventral (14.43%) and lateral wall (26.71%; P = 0.001). In Walking group, the plaques more likely occurred at the lateral (49.79%) and dorsal (35.07%) wall than at the ventral wall (14.86%, P = 0.02). Conclusions The geometric configurations of vertebrobasilar artery strongly influence the BA plaque locations. Further prospective studies are warranted to testify whether Hypoplasia-Lambda and Walking configurations are independent risk factors for pontine infarcts.

【 授权许可】

Unknown