Zunyimycins B and C, New Chloroanthrabenzoxocinones Antibiotics against Methicillin-Resistant Staphylococcus aureus and Enterococci from Streptomyces sp. FJS31-2

Molecules

Shengyan Qian¹  Changwu Yue¹  Ying Huang¹  Ning Liu¹  Yonglin Hu¹  Meiyun Shao¹  Yuxin Bao¹  Yingquan Wang¹  Yinyin Wang²  Zehui Chen²  Daishun Liu²  Chengmin Deng²  Yuhong Lü²  Miao Wang²  Xiaoqian Li²  Minghao Liu² 

[1] Drug Development, Zunyi Medical University, Zunyi 563003, Guizhou, China;;Guizhou Key Laboratory of Microbial Resources &

关键词: zunyimycins;    chloroanthrabenzoxocinones;    antibacterial;    activity;    MRSA;    Enterococci;    streptomycetes;   

DOI  :  10.3390/molecules22020251

来源: DOAJ

【 摘 要 】

This study performed an optimization of the fermentation conditions to activate the expression of the zunyimycin family biosynthesis genes of the zunyimycin-producing streptomycetes strain Streptomyces sp. FJS31-2. Bioassay-guided isolation and purification by varied chromatographic methods yielded two new compounds of the zunyimycin derivatives, namely, 31-2-7 and 31-2-8, accompanied with three known anthrabenzoxocinones family members of zunyimycin A, BE24566B, and chloroanthrabenzoxocinone. Their structures were elucidated by NMR, HRESIMS, IR, UV, and CD. Results showed that these two compounds were structurally similar to the previously reported compound zunyimycin A but differed in positions and number of chlorine atom substitution. The two novel compounds were called zunyimycins B and C. Antibacterial activity assay indicated that zunyimycin C showed a good inhibitory effect on the methicillin-resistant Staphylococcus aureus and Enterococci.

【 授权许可】

Unknown