Nimotuzumab for Patients With Inoperable Cancer of the Head and Neck

Frontiers in Oncology

Normando E. Iznaga Escobar¹  Zaima Mazorra Herrera²  Tania Crombet Ramos²  Braulio Mestre Fernández³ 

[1] Biocubafarma, Havana, Cuba;Center of Molecular Immunology, Havana, Cuba;Clinical Oncology, National Institute of Oncology and Radiobiology, Havana, Cuba;

关键词: nimotuzumab;    EGFR;    monoclonal antibody;    head and neck;    radiotherapy;   

DOI  :  10.3389/fonc.2020.00817

来源: DOAJ

【 摘 要 】

EGFR activation induces cell proliferation, neoformation of blood vessels, survival, and metastasis of the cancer cells. Nimotuzumab is an engineered, intermediate affinity anti-EGFR antibody, that apart from other drugs in its class, is very safe and does not cause hypomagnesemia or grade 3–4 cutaneous rash. The antibody inhibits cell proliferation and angiogenesis, activates natural killer cells, stimulates dendritic cell maturation, and induces cytotoxic T cells. Nimotuzumab restores MHC-I expression on tumor cells, hindering one of the EGFR immune-escape ways. The antibody has been extensively studied in 7 clinical trials, concurrently with irradiation or irradiation plus chemotherapy in subjects with inoperable head and neck tumors. Nimotuzumab was safe and efficacious in unfit patients receiving irradiation alone and in subjects treated with cisplatin and radiotherapy. In patients with locally advanced squamous cell carcinomas of the head and neck, nimotuzumab in combination with low dose cisplatin and radiotherapy was superior to cisplatin and radiotherapy in progression free survival, disease free survival, and locoregional tumor control.

【 授权许可】

Unknown