Reprogramming: Emerging Strategies to Rejuvenate Aging Cells and Tissues

International Journal of Molecular Sciences

Jean-Marc Lemaitre¹  Enora Le Borgne¹  Quentin Alle¹  Ollivier Milhavet² 

[1] IRMB, University of Montpellier, INSERM, 34295 Montpellier, France;IRMB, University of Montpellier, INSERM, CNRS, 34295 Montpellier, France;

关键词: aging;    senescence;    epigenetics;    stem cells;    reprogramming;    iPSC;   

DOI  :  10.3390/ijms22083990

来源: DOAJ

【 摘 要 】

Aging is associated with a progressive and functional decline of all tissues and a striking increase in many “age-related diseases”. Although aging has long been considered an inevitable process, strategies to delay and potentially even reverse the aging process have recently been developed. Here, we review emerging rejuvenation strategies that are based on reprogramming toward pluripotency. Some of these approaches may eventually lead to medical applications to improve healthspan and longevity.

【 授权许可】

Unknown