Effects of paeonol on proliferation and collagen synthesis of rat cardiac fibroblasts induced by aldosterone

Bangladesh Journal of Pharmacology

Li Na Wang¹  Qian Xu¹  Yan Hong Xiao¹  Jing Yi Zhao¹  Chao Du¹ 

[1] Department of Biochemistry, Chengde Medical University, Chengde 067000, Hebei, China.;

关键词: Aldosterone;    Paeonol;    TGF-β1;    Type I collagen;    Type III collagen;   

DOI  :  10.3329/bjp.v16i2.51605

来源: DOAJ

【 摘 要 】

The aim of this study was to explore the possible molecular mechanisms of paeonol in preventing ventricular remodeling. The cell viability of neonatal rat cardiac fibroblasts was detected by the method of MTT. RT-PCR and Western blot were used to measure the expression of TGF-β1, type I collagen and type III collagen. After treating the cardiac fibroblasts with paeonol, the cell viability decreased (p<0.01), and the expression of TGF-β1, type I collagen and types III collagen was significantly reduced (p<0.01). Thus, paeonol can inhibit the proliferation of fibroblast cells induced by aldosterone. The molecular mechanism is related to the down-regulation of TGF-β1 and type I and III collagen gene expression.

【 授权许可】

Unknown