Case Report: Response to Immunotherapy, Can Radiotherapy Be a Troublemaker?

Frontiers in Immunology

Jean-Yves Scoazec¹  Julien Adam¹  Antonin Levy²  Sébastien Gouy³  Antoine Hollebecque⁴  Aurélien Marabelle⁴  Stéphane Champiat⁴  Capucine Baldini⁴  Christophe Massard⁴  Patricia Martin-Romano⁴  Jean-Charles Soria⁶  Eric Deutsch⁶ 

[1] Department of Pathology, Gustave Roussy Cancer Campus, Villejuif, France;Department of Radiation Oncology, Gustave Roussy Cancer Campus, Villejuif, France;Department of Surgery, Gustave Roussy Cancer Campus, Villejuif, France;Early Drug Development Department (DITEP), Gustave Roussy Cancer Campus, Villejuif, France;Institut National de la Santé et de la Recherche Médicale (INSERM), Gustave Roussy Cancer Campus, Villejuif, France;Université Paris Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France;

关键词: immunotherapy;    radiation therapy;    tumor response;    immune microenvironment;    anal squamous cell carcinoma;   

DOI  :  10.3389/fimmu.2021.745146

来源: DOAJ

【 摘 要 】

Immunotherapy has dramatically changed the treatment landscape for several tumor types. However, the impact of previous radiotherapy (RT) on response to immunotherapy is still unknown. We report the case of a 58-year-old female diagnosed with a squamous anal cell carcinoma previously treated with RT and having a dissociated response to anti-PD1 agent. An extensive analysis of the immune contexture performed on the tissue collected from both previously RT-treated and RT-untreated lesions confirmed differences on immune microenvironment, highlighting the potential impact of radiotherapy on the immune response.

【 授权许可】

Unknown