Nigella sativa and Thymoquinone: A Natural Blessing for Periodontal Therapy

Antioxidants

Mohamed Mekhemar¹  Yasmine Hassan¹  Christof Dörfer¹ 

[1] Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian-Albrecht’s University, 24105 Kiel, Germany;

关键词: thymoquinone;    Nigella sativa;    periodontal disease;    periodontitis;    anti-inflammatories;    antioxidants;   

DOI  :  10.3390/antiox9121260

来源: DOAJ

【 摘 要 】

Thymoquinone (TQ), the chief active constituent of Nigella sativa (NS), shows very valuable biomedical properties such as antioxidant, antimicrobial, anticancer, anti-inflammatory, antihypertensive, hypoglycemic, antiparasitic and anti-asthmatic effects. Several studies have examined the pharmacological actions of TQ in the treatment of oral diseases but its potential role in periodontal therapy and regeneration is not yet fully defined. The present investigation has been designed to review the scientific studies about the effects of TQ as an adjunct to periodontal treatment to promote healing and periodontal regeneration. Along with clinical experiments, in vitro studies exhibit the beneficial effects of TQ during periodontal therapy. Nevertheless, additional comprehensive clinical and preclinical studies at cellular and molecular levels are essential to examine the particular action mechanisms of Nigella sativa and its elements, particularly TQ, during periodontal treatment or regeneration.

【 授权许可】

Unknown