Herpes simplex virus interference with immunity: Focus on dendritic cells

Virulence

Tognarelli EI¹  González PA¹  Duarte LF¹  Farías MA¹ 

[1] Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile;

关键词: dendritic cells;    hsv-1;    hsv-2;    immune evasion;    immunity;    t-cell;    unfolded protein response (upr);    autophagy;    apoptosis;   

DOI  :  10.1080/21505594.2021.1980990

来源: DOAJ

【 摘 要 】

Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are highly prevalent in the human population. These viruses cause lifelong infections by establishing latency in neurons and undergo sporadic reactivations that promote recurrent disease and new infections. The success of HSVs in persisting in infected individuals is likely due to their multiple molecular determinants involved in escaping the host antiviral and immune responses. Importantly, HSVs infect and negatively modulate the function of dendritic cells (DCs), key immune cells that are involved in establishing effective and balanced immunity against viruses. Here, we review and discuss several molecular and cellular processes modulated by HSVs in DCs, such as autophagy, apoptosis, and the unfolded protein response. Given the central role of DCs in establishing optimal antiviral immunity, particular emphasis should be given to the outcome of the interactions occurring between HSVs and DCs.

【 授权许可】

Unknown