Potency and Selectivity of SMAC/DIABLO Mimetics in Solid Tumor Therapy

Cells

Xiu-Yun Wang¹  Qi-Yao Wei¹  Xiao-Yun Zhao¹  Yan-Ming Xu¹  Andy T. Y. Lau¹ 

[1] Laboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong 515041, China;

关键词: inhibitor of apoptosis protein (IAP);    second mitochondria-derived activator of caspase (SMAC);    direct IAP-binding protein with low pI (DIABLO);    SMAC mimetics (SMs);    clinical trial;    therapy;   

DOI  :  10.3390/cells9041012

来源: DOAJ

【 摘 要 】

Aiming to promote cancer cell apoptosis is a mainstream strategy of cancer therapy. The second mitochondria-derived activator of caspase (SMAC)/direct inhibitor of apoptosis protein (IAP)-binding protein with low pI (DIABLO) protein is an essential and endogenous antagonist of inhibitor of apoptosis proteins (IAPs). SMAC mimetics (SMs) are a series of synthetically chemical compounds. Via database analysis and literature searching, we summarize the potential mechanisms of endogenous SMAC inefficiency, degradation, mutation, releasing blockage, and depression. We review the development of SMs, as well as preclinical and clinical outcomes of SMs in solid tumor treatment, and we analyze their strengths, weaknesses, opportunities, and threats from our point of view. We also highlight several questions in need of further investigation.

【 授权许可】

Unknown