Roles of Long Non-coding RNAs in the Development of Aging-Related Neurodegenerative Diseases

Frontiers in Molecular Neuroscience

You-Shuo Liu²  Hui Xu²  Yu-Qing Ni² 

[1] Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, China;Institute of Aging and Age-Related Disease Research, Central South University, Changsha, China;

关键词: long non-coding RNAs;    ageing;    neurodegenerative diseases;    Alzheimer’s disease;    Parkinson’s disease;    Huntington’s disease;   

DOI  :  10.3389/fnmol.2022.844193

来源: DOAJ

【 摘 要 】

Aging-related neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), are gradually becoming the primary burden of society and cause significant health-care concerns. Aging is a critical independent risk factor for neurodegenerative diseases. The pathological alterations of neurodegenerative diseases are tightly associated with mitochondrial dysfunction, inflammation, and oxidative stress, which in turn stimulates the further progression of neurodegenerative diseases. Given the potential research value, lncRNAs have attracted considerable attention. LncRNAs play complex and dynamic roles in multiple signal transduction axis of neurodegeneration. Emerging evidence indicates that lncRNAs exert crucial regulatory effects in the initiation and development of aging-related neurodegenerative diseases. This review compiles the underlying pathological mechanisms of aging and related neurodegenerative diseases. Besides, we discuss the roles of lncRNAs in aging. In addition, the crosstalk and network of lncRNAs in neurodegenerative diseases are also explored.

【 授权许可】

Unknown