Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System

International Journal of Molecular Sciences

GenieveEe Chia Yeo¹  FazlinaBinti Nordin¹  JiaXian Law¹  MinHwei Ng¹ 

[1]Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Cheras 56000, Malaysia

关键词: mesenchymal stem cells;    aging;    inflammaging;    frailty;    immune system;   

DOI  :  10.3390/ijms22115749

来源: DOAJ

【 摘 要 】

Rapid growth of the geriatric population has been made possible with advancements in pharmaceutical and health sciences. Hence, age-associated diseases are becoming more common. Aging encompasses deterioration of the immune system, known as immunosenescence. Dysregulation of the immune cell production, differentiation, and functioning lead to a chronic subclinical inflammatory state termed inflammaging. The hallmarks of the aging immune system are decreased naïve cells, increased memory cells, and increased serum levels of pro-inflammatory cytokines. Mesenchymal stem cell (MSC) transplantation is a promising solution to halt immunosenescence as the cells have excellent immunomodulatory functions and low immunogenicity. This review compiles the present knowledge of the causes and changes of the aging immune system and the potential of MSC transplantation as a regenerative therapy for immunosenescence.

【 授权许可】

Unknown