Synergistic effects of aerobic exercise and cognitive training on cognition, physiological markers, daily function, and quality of life in stroke survivors with cognitive decline: study protocol for a randomized controlled trial

Trials

Ku-chou Chang¹  Ching-yi Wu²  Yu-wei Hsieh²  Yi-han Liao²  Ching-hung Teng²  Lin-chien Lee³  Jen-wen Hung⁴  Ting-ting Yeh⁵  Keh-chung Lin⁵ 

[1] Department of Neurology, Chang Gung Memorial Hospital;Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University;Department of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital;Department of Rehabilitation, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University, College of Medicine;School of Occupational Therapy, College of Medicine, National Taiwan University;

关键词: Stroke;    Cognitive rehabilitation;    Aerobic exercise;    Cognitive training;    Sequential training;   

DOI  :  10.1186/s13063-017-2153-7

来源: DOAJ

【 摘 要 】

Abstract Background Aerobic exercise and cognitive training have been effective in improving cognitive functions; however, whether the combination of these two can further enhance cognition and clinical outcomes in stroke survivors with cognitive decline remains unknown. This study aimed to determine the treatment effects of a sequential combination of aerobic exercise and cognitive training on cognitive function and clinical outcomes. Methods/design Stroke survivors (n = 75) with cognitive decline will be recruited and randomly assigned to cognitive training, aerobic exercise, and sequential combination of aerobic exercise and cognitive training groups. All participants will receive training for 60 minutes per day, 3 days per week for 12 weeks. The aerobic exercise group will receive stationary bicycle training, the cognitive training group will receive cognitive-based training, and the sequential group will first receive 30 minutes of aerobic exercise, followed by 30 minutes of cognitive training. The outcome measures involve cognitive functions, physiological biomarkers, daily function and quality of life, physical functions, and social participation. Participants will be assessed before and immediately after the interventions, and 6 months after the interventions. Repeated measures of analysis of variance will be used to evaluate the changes in outcome measures at the three assessments. Discussion This trial aims to explore the benefits of innovative intervention approaches to improve the cognitive function, physiological markers, daily function, and quality of life in stroke survivors with cognitive decline. The findings will provide evidence to advance post-stroke cognitive rehabilitation. Trial registration ClinicalTrials.gov, NCT02550990 . Registered on 6 September 2015.

【 授权许可】

Unknown