Neurological Infection, Kynurenine Pathway, and Parasitic Infection by Neospora caninum

Frontiers in Immunology

Alexandre Moraes Pinheiro¹  Ana Elisa Del’Arco¹  Deivison Silva Argolo²  Maria de Fátima Dias Costa²  Silvia Lima Costa²  Gilles Guillemin³ 

[1]Laboratory of Biochemistry and Veterinary Immunology, Center of Agrarian, Environmental and Biological Sciences, Federal University of Recôncavo of Bahia (UFRB), Cruz das Almas, Brazil

[2]Laboratory of Neurochemistry and Cellular Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia (UFBA), Bahia, Brazil

[3]Neuroinflammation Group, Macquarie Medicine School, Macquarie University, Sydney, NSW, Australia

关键词: kynurenic acid;    glia;    neuroinflammation;    Neospora caninum;    quinolinic acid;   

DOI  :  10.3389/fimmu.2021.714248

来源: DOAJ

【 摘 要 】

Neuroinflammation is one of the most frequently studied topics of neurosciences as it is a common feature in almost all neurological disorders. Although the primary function of neuroinflammation is to protect the nervous system from an insult, the complex and sequential response of activated glial cells can lead to neurological damage. Depending on the type of insults and the time post-insult, the inflammatory response can be neuroprotective, neurotoxic, or, depending on the glial cell types, both. There are multiple pathways activated and many bioactive intermediates are released during neuroinflammation. One of the most common one is the kynurenine pathway, catabolizing tryptophan, which is involved in immune regulation, neuroprotection, and neurotoxicity. Different models have been used to study the kynurenine pathway metabolites to understand their involvements in the development and maintenance of the inflammatory processes triggered by infections. Among them, the parasitic infection Neospora caninum could be used as a relevant model to study the role of the kynurenine pathway in the neuroinflammatory response and the subset of cells involved.

【 授权许可】

Unknown