DNA-Templated Fluorescent Silver Nanoclusters Inhibit Bacterial Growth While Being Non-Toxic to Mammalian Cells

Molecules

Liam Yourston¹  Nolan Marshall¹  Alexey V. Krasnoslobodtsev¹  Kirill A. Afonin²  Leyla Danai²  Damian Beasock²  Seraphim Kozlov²  Morgan Chandler²  Oleg Shevchenko²  Lewis Rolband² 

[1] Department of Physics, University of Nebraska at Omaha, Omaha, NE 68182, USA;Nanoscale Science Program, Department of Chemistry, University of North Carolina at Charlotte, Charlotte, NC 28223, USA;

关键词: DNA;    silver;    AgNC;    nanocluster;    antibacterial;    fluorescence;   

DOI  :  10.3390/molecules26134045

来源: DOAJ

【 摘 要 】

Silver has a long history of antibacterial effectiveness. The combination of atomically precise metal nanoclusters with the field of nucleic acid nanotechnology has given rise to DNA-templated silver nanoclusters (DNA-AgNCs) which can be engineered with reproducible and unique fluorescent properties and antibacterial activity. Furthermore, cytosine-rich single-stranded DNA oligonucleotides designed to fold into hairpin structures improve the stability of AgNCs and additionally modulate their antibacterial properties and the quality of observed fluorescent signals. In this work, we characterize the sequence-specific fluorescence and composition of four representative DNA-AgNCs, compare their corresponding antibacterial effectiveness at different pH, and assess cytotoxicity to several mammalian cell lines.

【 授权许可】

Unknown