Role of Epstein–Barr Virus in the Pathogenesis of Head and Neck Cancers and Its Potential as an Immunotherapeutic Target

Frontiers in Oncology

Shahab Uddin¹  Varghese Philipose Inchakalody²  Nassima Abdelouahab²  Said Dermime²  Maysaloun Merhi²  Afsheen Raza²  Queenie Fernandes²  Abdul Rehman Zar Gul² 

[1] Interim Translational Research Institute, Hamad Medical Corporation, Doha, Qatar;National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar;Translational Cancer Research Facility, Hamad Medical Corporation, Doha, Qatar;

关键词: Epstein–Barr virus;    head and neck cancers;    nasopharyngeal cancer;    EBV-induced nuclear antigen 1;    LMP;    cancer vaccine;   

DOI  :  10.3389/fonc.2018.00257

来源: DOAJ

【 摘 要 】

The role of Epstein–Barr virus (EBV) infection in the development and progression of tumor cells has been described in various cancers. Etiologically, EBV is a causative agent in certain variants of head and neck cancers such as nasopharyngeal cancer. Proteins expressed by the EVB genome are involved in invoking and perpetuating the oncogenic properties of the virus. However, these protein products were also identified as important targets for therapeutic research in the past decades, particularly within the context of immunotherapy. The adoptive transfer of EBV-targeted T-cells as well as the development of EBV vaccines has opened newer lines of research to conceptualize novel therapeutic approaches toward the disease. This review addresses the most important aspects of the association of EBV with head and neck cancers from an immunological perspective. It also aims to highlight the current and future prospects of enhanced EBV-targeted immunotherapies.

【 授权许可】

Unknown