Microwave-Assisted Knoevenagel-Doebner Reaction: An Efficient Method for Naturally Occurring Phenolic Acids Synthesis

Frontiers in Chemistry

关键词: p-hydroxycinnamic acids;    ferulic acid;    Sinapic acid;    Caffeic acid;    Coumaric acid;    Knoevenagel-Doebner;   

DOI  :  10.3389/fchem.2018.00426

来源: DOAJ

【 摘 要 】

The common chemical method to synthesize Phenolic Acids (PAs) involves a relatively considerable energy intake. In order to solve this issue, microwave-assisted Knoevenagel-Doebner condensations were developed. Nevertheless, these synthetic procedures prove difficult to reproduce. Herein, we developed and optimized—by using a combination of a Design of Experiment and a standard optimization approach—a reliable procedure that converts naturally occuring p-hydroxybenzaldehydes into the corresponding PAs with conversions of 86–99% and in 85–97% yields.

【 授权许可】

Unknown