Wearable Label‐Free Optical Biodetectors: Progress and Perspectives

Advanced Photonics Research

Sivanantha Raja Avaninathan¹  Shanmuga Sundar Dhanabalan²  Sharath Sriram²  Sumeet Walia²  Madhu Bhaskaran²  Marcos Flores Carrasco³ 

[1] Electronics and Communication Engineering Department Alagappa Chettiar Government College of Engineering and Technology Karaikudi 630003 Tamilnadu, India;Functional Materials and Microsystems Research Group and the Micro Nano Research Facility RMIT University GPO Box 2476 Melbourne, Victoria 3001 Australia;Surfaces and Nanomaterials Laboratory Faculty of Physical Science and Mathematics University of Chile Beauchef 850 Santiago Chile;

关键词: biomarkers;    biosensors;    label-free;    optical detection;    optical technology;    wearables;   

DOI  :  10.1002/adpr.202000076

来源: DOAJ

【 摘 要 】

Biomarkers are the primary indicators of human health. Measurements traditionally rely on targeted binding and assays, which, in turn, rely on specific “labels” that define the biomarker or molecule of interest. While selective and specific, label‐based approaches limit the range of biomarkers a technology can detect. Technologies that can detect and analyze a broad range of biomarkers offer versatility, especially rapid repurposing for new targets. Optical technologies for label‐free biomarker sensing enable noninvasive, minimal‐contact, and wearable or point‐of‐care rapid diagnostic measurements. Herein, label‐free biomarker detection is reviewed with an emphasis on progress toward miniaturized and noninvasive wearable devices. Compact light‐emitting devices and optical detection technologies are presented, tailored for a large range of biomarkers, including recent advances in battery‐free devices. Label‐free detection is reusable, reagent‐free, and allows continuous long‐term monitoring. The potential for optical technologies for label‐free detection in terms of integration, device design, and future applications is summarized.

【 授权许可】

Unknown