New insight and potential therapy for NAFLD: CYP2E1 and flavonoids

Biomedicine & Pharmacotherapy

Xiumei Gao¹  Xiao Liu²  Wangxiao Tan²  Lina Deng²  Xiaoying Wang²  Kaiyue Wang²  Lu Huang² 

[1] College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China;State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China;

关键词: NAFLD;    NAFL;    NASH;    Flavonoids;    CYP2E1;   

DOI  :  

来源: DOAJ

【 摘 要 】

Over the years, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased year by year; however, due to its complicated pathogenesis, there is no effective treatment so far. It is reported that Cytochrome P450 2E1 (CYP2E1) plays an indispensable role in the development of NAFLD, and numerous studies have shown that flavonoids have a hepatoprotective effect and can exert a beneficial effect on NAFLD by regulating the activity of CYP2E1. Therefore, flavonoids may become effective drugs for the treatment of NAFLD in the future. This prompted us to review the research progress of the pathological mechanism of NAFLD and the impact of CYP2E1 activity changes during the pathological process, and to summarize the protective effect of flavonoids against CYP2E1 activity.

【 授权许可】

Unknown