Structural, biochemical, and functional properties of the Rap1-Interacting Adaptor Molecule (RIAM)

Biomedical Journal

Esther M. Lafuente¹  Nikolaos Patsoukis²  Duygu Sari-Ak³  Vassiliki A. Boussiotis⁴  Anthos Christofides⁴  Yavuz-Furkan Yazicioglu⁵  Alvaro Torres-Gomez⁶ 

[1] Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA;Department of Medicine, Harvard Medical School, Boston, USA;Department of Medical Biology, School of Medicine, University of Health Sciences, Istanbul, Turkey;Division of Hematology-Oncology, Harvard Medical School, Boston, USA;Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK;School of Medicine, Unit of Immunology, Complutense University of Madrid, Madrid, Spain;

关键词: Leukocytes;    Integrins;    Rap1;    RIAM;    Adhesion;    Phagocytosis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Leukocytes, the leading players of immune system, are involved in innate and adaptive immune responses. Leukocyte adhesion to endothelial cells during transmigration or to antigen presenting cells during T cell activation, requires integrin activation through a process termed inside-out integrin signaling. In hematopoietic cells, Rap1 and its downstream effector RIAM (Rap1-interacting adaptor molecule) form a cornerstone for inside-out integrin activation. The Rap1/RIAM pathway is involved in signal integration for activation, actin remodeling and cytoskeletal reorganization in T cells, as well as in myeloid cell differentiation and function. RIAM is instrumental for phagocytosis, a process requiring particle recognition, cytoskeletal remodeling and membrane protrusion for engulfment and digestion. In the present review, we discuss the structural and molecular properties of RIAM and the recent discoveries regarding the functional role of the Rap1/RIAM module in hematopoietic cells.

【 授权许可】

Unknown