Two New Guaiane Sesquiterpenoids from Daphne holosericea (Diels) Hamaya

Molecules

Yan Hua¹  Yi-Chun Chen¹  You-Xing Zhao²  Zhi-Kai Guo²  Sheng-Zhuo Huang²  Hao-Fu Dai²  Qing-Yun Ma² 

[1] College of Forestry, Southwest Forestry University, Kunming 650224, Yunnan, China;Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China;

关键词: Thymelaeaceae;    Daphne holosericea;    guaiane sesquiterpenoids;    acetylcholinesterase inhibition;   

DOI  :  10.3390/molecules190914266

来源: DOAJ

【 摘 要 】

Two new sesquiterpenoids with guaiane skeletons—holosericin A (1) and holosericin B (2)—were isolated from the medicinal plant Daphne holosericea (Diels) Hamawa (Thymelaeceae). Their structures were elucidated by 1D and 2D-NMR spectroscopy, as well as HR-ESI-MS data. Compounds 1 and 2 were evaluated for inhibitory activities against acetylcholinesterase and compound 2 showed a moderate activity with 31% inhibition.

【 授权许可】

Unknown