Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats

Journal of Functional Foods

Robson C. Veras¹  Islania G.A. Araújo¹  Mayara P. Melo¹  Isac A. Medeiros¹  Pablo F. Santos¹  Natália T.M. Calzerra²  Angela M.T.M. Cordeiro³  Bruno R.L.A. Meireles³  Priscilla M.P. Maciel⁴  Renata L.P. Vieira⁴  Kívia S. Assis⁴  Fátima de L.A.A. Azevedo⁴ 

[1] Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde (CCS), Universidade Federal da Paraíba, Cidade Universitária, Campus I, João Pessoa, Paraíba 58.059-900, Brazil;Departamento de Fisiologia e Farmacologia, Centro de Biociências (CB), Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco 50670901, Brasil;Departamento de Tecnologia de Alimentos, Centro de Tecnologia e Desenvolvimento Regional, Universidade Federal de Paraíba, Campus I, João Pessoa, Paraíba 58055-000, Brazil;Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba (UFPB), João Pessoa 58059-900, Brazil;

关键词: Essential hypertension;    Brazilian red wine;    Endothelial dysfunction;    Vascular alterations;    Mesenteric resistance arteries;    Spontaneously hypertensive rats;   

DOI  :  

来源: DOAJ

【 摘 要 】

Moderate consumption of wine has a protective effect on the cardiovascular system. This study proposes to investigate the cardiovascular protective effect of the lyophilized red wine RIO SOL Cabernet-Sauvignon (LRW-RSCS), produced in Northeastern Brazil, in SHR. Sixteen different phenolic compounds, such as gentisic acid, catechin, and resveratrol were identified in LRW-RSCS using high-performance liquid chromatography. LRW-RSCS presented anti-radical activity. Six-week treatment of SHR with LRW-RSCS (100 or 300 mg/Kg/day intra-gastrically) reduced blood pressure and hypercontractility, and improved mesenteric resistance artery endothelial function. The protective effect of LRW-RSCS on endothelial function, mediated relaxation involving both higher endothelial-NO and -EDHF. LRW-RSCS intake reduced vessel wall thickness, media-to-lumen ratio, collagen vascular deposition, and vessel oxidative stress. LRW-RSCS also attenuated platelet hyper aggregation and ROS generation. The results demonstrate that LRW-RSCS from Northeastern Brazil presents cardiovascular protective effect in SHR, at least in part by decreasing oxidative stress.

【 授权许可】

Unknown