Dietary geraniol by oral or enema administration strongly reduces dysbiosis and systemic inflammation in dextran sulphate sodium-treated mice.

Frontiers in Pharmacology

Massimo eCampieri¹  Fernando eRizzello¹  Elena eCavazza¹  Luigia eDe Fazio¹  Manuela eCentanni¹  Maria Chiara Valerii¹  Antonio eStrillacci¹  Enzo eSpisni¹  Marco eCandela¹  Chiara eRicci² 

[1] University of Bologna;University of Brescia;

关键词: Inflammation;    Geraniol;    Cyclooxygenase-2 (COX-2);    Inflammatory bowel disease (IBD);    Dextran sulphate sodium (DSS)-induced colitis;    Dysbiosis.;   

DOI  :  10.3389/fphar.2016.00038

来源: DOAJ

【 摘 要 】

(Trans)-3,7-Dimethyl-2,6-octadien-1-ol, commonly called geraniol (Ge-OH), is an acyclic monoterpene alcohol with well-known anti-inflammatory, antitumoral and antimicrobial properties. It is widely used as a preservative in the food industry and as an antimicrobial agent in animal farming. The present study investigated the role of Ge-OH as an anti-inflammatory and anti-dysbiotic agent in the dextran sulphate sodium (DSS)-induced colitis mouse model. Ge-OH was orally administered to C57BL/6 mice at daily doses of 30 and 120mg kg(-1) body weight, starting six days before DSS treatment and ending the day after DSS removal. Furthermore, Ge-OH 120 mg kg(-1) dose body weight was administered via enema during the acute phase of colitis to facilitate its on-site action. The results show that orally or enema-administered Ge-OH is a powerful antimicrobial agent able to prevent colitis-associated dysbiosis and decrease the inflammatory systemic profile of colitic mice. As a whole, Ge-OH strongly improved the clinical signs of colitis and significantly reduced cyclooxygenase-2 (COX-2) expression in colonocytes and in the gut wall. Ge-OH could be a powerful drug for the treatment of intestinal inflammation and dysbiosis.

【 授权许可】

Unknown