EXTRA-CORPOREAL PHOTOCHEMOTHERAPY IN THE TREATMENT OF LYMPHOMATOID PAPULOSIS AND FOLLICULOTROPIC MYCOSIS FUNGOIDES: CASE REPORTS

Alʹmanah Kliničeskoj Mediciny

O. V. Karzanov¹  N. M. Aleksandrovа²  A. V. Kil’dyushevskiy² 

[1] 61/2 Shchepkina ul., Moscow, 129110, Russian Federation;Moscow Regional Research and Clinical Institute (MONIKI);

关键词: lymphoma;    lymphomatoid papulosis;    folliculotropic mycosis fungoides;    extra-corporeal photochemotherapy;    photopheresis;   

DOI  :  10.18786/2072-0505-2014-34-81-84

来源: DOAJ

【 摘 要 】

Aim: To assess clinical efficacy of extra-corporeal photochemotherapy (EPCT) in the treatment of rare lymphomas  – lymphomatoid papulosis and folliculotropic mycosis fungoides. Materials and methods: This is a presentation of two cases of lymphomatoid papulosis and folliculotropic mycosis fungoides treated with EPCT with duration of follow-up 9 and 12  years. Extracorporeal photochemotherapy involved administration of 8-methoxypsoralen 0.6 mg/kg 1.5–2 hours before the initiation of intermittent flow separation of mononuclear cells using Haemonetics MCS+ blood cells separator and corresponding protocol. Cell suspension was exposed to UVA-radiation (λ=320–400  nm) using blood irradiator Julia (10–15 ml/min) during 30 minutes then re-infused. In total, 4 procedures were conducted every other day. Results: Both patients demonstrated positive effect involving regression of the rashes after 3 EPCT cycles. Subsequently, the patients received maintenance EPCT 2–3 times a year. Conclusion: High clinical efficacy of EPCT was demonstrated in 2  patients with lymphomatoid papulosis and folliculotropic mycosis fungoides after 9 and 12 years of follow-up.

【 授权许可】

Unknown