Theories and quantification of thymic selection

Frontiers in Immunology

Andrew eYates¹ 

[1] Albert Einstein College of Medicine;

关键词: T cells;    mathematical modeling;    theoretical biology;    Repertoire selection;    Thymic selection;   

DOI  :  10.3389/fimmu.2014.00013

来源: DOAJ

【 摘 要 】

The peripheral T cell repertoire is sculpted from prototypic T cells in the thymus bearing randomly generated T cell receptors (TCR) and by a series of developmental and selection steps that remove cells that are unresponsive or overly-reactive to self-peptide MHC complexes. The challenge of understandinghow the kinetics of T cell development and the statistics of the selection processes combine to provide a diverse but self-tolerant T cell repertoire has invited quantitative modeling approaches, which we review here.

【 授权许可】

Unknown