Challenges and new opportunities for detecting endogenous opioid peptides in reward

Addiction Neuroscience

Ream Al-Hasani¹  Marwa O. Mikati²  Sineadh M. Conway³ 

[1] Center for Clinical Pharmacology, University of Health Sciences and Pharmacy &Washington University Pain Center, Washington University, St. Louis, MO, USA;Department of Anesthesiology, Washington University, St. Louis, MO, USA;

关键词: Opioid peptides;    Enkephalin;    Dynorphin;    β-endorphin;    Drug reward;    Food reward;   

DOI  :  

来源: DOAJ

【 摘 要 】

The endogenous opioid peptide system, comprised of enkephalins, endorphins, dynorphins, and nociceptin, is a highly complex neurobiological system. Opioid peptides are derived from four precursor molecules and undergo several processing events yielding over 20 unique opioid peptides. This diversity together with low in vivo concentration and complex processing and release dynamics has challenged research into each peptide's unique function. Despite the subsequent challenges in detecting and quantifying opioid peptides in vivo, researchers have pioneered several techniques to directly or indirectly assay the roles of opioid peptides during behavioral manipulations. In this review, we describe the limitations of the traditional techniques used to study the role of endogenous opioid peptides in food and drug reward and bring focus to the wealth of new techniques to measure endogenous opioid peptides in reward processing.

【 授权许可】

Unknown