A Novel Pyroptosis-Related lncRNA Signature for Predicting the Prognosis of Skin Cutaneous Melanoma

International Journal of General Medicine

关键词: melanoma;    pyroptosis;    programmed cell death;    immunotherapy;    bioinformatics;   

DOI  :  

来源: DOAJ

【 摘 要 】

Jiaheng Xie,1,* Haobo Li,2,* Liang Chen,3,* Yuan Cao,4,* Yiming Hu,5 Zhechen Zhu,1 Ming Wang,1 Jingping Shi1 1Department of Burn and Plastic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 3Department of General Surgery, Fuyang Hospital Affiliated to Anhui Medical University, Fuyang, Anhui, People’s Republic of China; 4Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 5College of Pharmacy, Jiangsu Ocean University, Lianyungang, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jingping Shi; Ming WangDepartment of Burn and Plastic Surgery, The First Hospital Affiliated to Nanjing Medical University, Guangzhou Road 300, Nanjing, Jiangsu, 210029, People’s Republic of ChinaTel [phone]Email [e-mail]; [e-mail]: To construct a prognosis model of melanoma based on pyroptosis related genes.Methods: Melanoma RNA-sequencing data was downloaded from TCGA. First, the lnRNAs related to pyroptosis were obtained through Pearson correlation analysis. Then, the prognosis model of pyroptosis related genes was constructed by Cox regression and Lasso regression. Melanoma patients were divided into high-risk and low-risk groups by risk score, and the differences in prognosis and immune microenvironment between the two groups were explored.Results: We found that the high-risk group had a significantly poorer prognosis, and different groups differed in immune infiltration, m6A methylation, and immune checkpoint.Conclusion: Our prognostic model can provide a reference for the study of pyroptosis in melanoma cells and provide a new idea for melanoma treatment.Keywords: melanoma, pyroptosis, programmed cell death, immunotherapy, bioinformatics

【 授权许可】

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