Effect of chromium enriched fermentation product of barley and brewer’s yeast and its combination with rosiglitazone on experimentally induced hyperglycaemia in mice

Srpski Arhiv za Celokupno Lekarstvo

关键词: barley and brewer’s yeast extract;    rosiglitazone;    alloxan;    diabetes mellitus;    pancreas;    histology;   

DOI  :  10.2298/SARH1110610C

来源: DOAJ

【 摘 要 】

Introduction. In the recent years, herbal preparations have been more used totreat diabetes. Dietetic supplement based on barley and beer yeast enrichedwith chromium (BBCr) is registered in Serbia as a supplement in the treatmentof type 2 diabetes. Objective. To investigate the effect of the preparationbased on barley and brewer’s yeast with chromium (BBCr), rosiglitazone (R)and their combination (BBCr+R) on fasting glycaemia and glycaemia in miceafter glucose, adrenalin and alloxan application. Methods. The animals weredivided into three groups: glucose 500 mg/kg (I); adrenalin 0.2 mg/kg (II);and alloxan 100 mg/kg (III) and into subgroups according to the substancethey received (BBCr: 750 mg/kg, R: 0.75 mg/kg and BBCr+R). Each animal wasits own control in respect of glycaemia before and after the treatment withtest substances, except for group III which contained a placebo subgroup.Results. BBCr caused a significant decrease of fasting glycaemia andsignificant reduction of glycaemia after glucose load compared to the valuesbefore treatment (7.4±0.6 mmol/l vs 9.2±0.6 mmol/l; p=0.01). R and BBCr+Rsignificantly decreased glycaemia after adrenalin load (R: 8.6±1.8 mmol/l vs15.4±3.2 mmol/l; p=0.004; BBCr+R: 9.6±2.4 mmol/l vs 15.0±4.4 mmol/l; p=0.04).After alloxan application the glycaemia was significantly lower in thesubgroups treated with BBCr, R and BBCr+R compared to placebo subgroup(10.1±8.0 mmol/l vs 6.8±2.7 mmol/l vs 13.5±9.7 mmol/l vs 24.5±4.7 mmol/l;p=0.001). Conclusion. Pretreatment with BBCr caused a significant reductionof fasting glycaemia and glycaemia after glucose load. Rosiglitazone andBBCr+R caused a significant reduction of glycaemia after adrenalin load.Pretreatment with BBCr, R and BBCr+R prevented the onset of experimentaldiabetes caused by alloxan, which was confirmed by histological analysis ofpancreas tissue.

【 授权许可】

Unknown