期刊论文详细信息
Heliyon
Synthesis, antibacterial properties and bioinformatics computational analyses of novel 8-hydroxyquinoline derivatives
Saida Messgo-Moumene1  Faisal Almalki2  Taibi Ben Hadda2  Abbelkader Zarrouk3  Siham Jabli4  Mohamed Ouhssine4  Younes Lakhrissi5  Mohamed Rbaa5  Brahim Lakhrissi6 
[1] Corresponding author.;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah Almukkarramah, Saudi Arabia;Laboratory for Research on Medicinal and Aromatic Plants, Science and Life Faculty, University of Blida 1, PO Box 270, Soumaa Road, 09100, Blida, Algeria;Laboratory of Agro Physiology, Biotechnology, Environment and Quality, Department of Biology, Faculty of Sciences, Ibn Tofail University, PO Box 133, 14000, Kenitra, Morocco;Laboratory of Agro-resources, Polymers and Process Engineering, Department of Chemistry, Faculty of Sciences, Ibn Tofaïl University, PO Box 133, 14000, Kenitra, Morocco;Laboratory of Materials, Nanotechnology and Environment, Faculty of Sciences, Mohammed V University, Ibn Battouta Avenue, PO Box 1014, Agdal, Rabat, Morocco;
关键词: Biochemistry;    Microbiology;    8-hydroxyquinoline;    Characterization;    Antimicrobial activity;    Antibacterial pharmacophore site;   
DOI  :  
来源: DOAJ
【 摘 要 】

New heterocyclic derivatives of 8-hydroxyquinoline were prepared and screened as antimicrobial agents. Chemical structures were elucidated and confirmed using different spectroscopic methods such as elemental analysis data, Infrared, Nuclear Magnetic Resonance Spectroscopy. In order to explore their potential biological activity, the “in vitro” antibacterial activity was investigated against [E. coli (ATCC35218), S. aureus (ATCC29213), V. parahaemolyticus (ATCC17802), and P. aeruginosa (ATCC27853)]. The studied compounds exhibited a remarkable antibacterial activity superior to the standard antibiotic (Penicillin G). These new heterocyclic derivatives of 8-hydroxyquinoline, which proved to be potentially effective, can be used as alternative chemical antimicrobial agents applications. It was very interesting to observe that POM (Petra/Osiris/Molinspiration) bioinformatic analyses of the 8-hydroxyquinoline derivative (5) exhibited more important antibacterial activity (MIC = 10−6 mg/mL against V.p and S.a bacteria) and good drug score (DS = 0.71) when compared with Penicillin (DS = 0.33; MIC = 10−3 mg/mL).

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