Recent Progress in Charged Polymer Chains Grafted by Radiation-Induced Graft Polymerization; Adsorption of Proteins and Immobilization of Inorganic Precipitates

Quantum Beam Science

Ryo Ishihara¹  Shiho Asai²  and Kyoichi Saito³ 

[1] Department of General Education, Faculty of Medicine, Juntendo University, 1-1 Hirakagakuendai, Inzai, Chiba 270-1695, Japan;National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST), Umezono 1-1-1, Tsukuba, Ibaraki 305-8563, Japan;Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan;

关键词: charged graft chain;    radiation-induced graft polymerization;    porous hollow-fiber membrane;    protein capture;    fibrous adsorbent;    cesium removal;   

DOI  :  10.3390/qubs4020020

来源: DOAJ

【 摘 要 】

Radiation-induced graft polymerization provides industrially superior functionalization schemes by selection of existing polymer substrates and design of graft chains. In this review, by a pre-irradiation method of the radiation-induced graft polymerization and subsequent chemical modifications, charged polymer chains grafted onto various components and shapes of the polymer substrates are described. The charged graft chains immobilized onto a porous hollow-fiber membrane captured proteins in multilayers via multipoint binding. A membrane onto which positively charged graft chains are immobilized, i.e., an anion-exchange porous hollow-fiber membrane, was commercialized in 2011 for the removal of undesirable proteins in the purification of pharmaceuticals. On the other hand, a membrane onto which negatively charged graft chains are immobilized, i.e., a cation-exchange porous hollow-fiber membrane, exhibited a low permeation flux for pure water; however, the prepermeation of an aqueous solution of magnesium chloride through the membrane restored the permeation flux because of ionic crosslinking of graft chains with magnesium ions. The charged graft chains provide a precipitation field for inorganic compounds such as insoluble cobalt ferrocyanide. The graft chains entangle or penetrate a precipitate owing to electrostatic interactions with the surface charge on the precipitate. Braids and wound filters composed of insoluble-cobalt-ferrocyanide-impregnated fibers are used for the removal of radiocesium from contaminated water at Tokyo Electric Power Co. (TEPCO) Fukushima Daiichi Nuclear Power Plant.

【 授权许可】

Unknown