Controlled Anchoring of (Phenylureido)sulfonamide-Based Receptor Moieties: An Impact of Binding Site Multiplication on Complexation Properties

Molecules

Václav Eigner¹  Karolína Salvadori²  Monika Müllerová²  Lucie Červenková Šťastná²  Alena Krupková²  Petra Cuřínová²  Tomáš Strašák² 

[1] Department of Solid State Chemistry, University of Chemistry and Technology Prague, Technická 5, 16828 Prague 6, Czech Republic;Institute of Chemical Process Fundamentals of CAS, v.v.i., Rozvojová 135, 16502 Prague 6, Czech Republic;

关键词: host-guest chemistry;    dendrimers;    supramolecular chemistry;   

DOI  :  10.3390/molecules26185670

来源: DOAJ

【 摘 要 】

The repetition of urea-based binding units within the receptor structure does not only lead to monomer properties multiplication. As confirmed by spectroscopic studies, UV-Vis and ¹H-NMR in classical or competitive titration mode, the attachment to a carrier allocates the active moieties to mutual positions predetermining the function of the whole receptor molecule. Bivalent receptors form self-aggregates. Dendritic receptors with low dihydrogen phosphate loadings offer a cooperative complexation mode associated with a positive dendritic effect. In higher dihydrogen phosphate concentrations, the dendritic branches act independently and the binding mode changes to 1:1 anion: complexation site. Despite the anchoring, the dendritic receptors retain the superior efficiency and selectivity of a monomer, paving the way to recyclable receptors, desirable for economic and ecological reasons.

【 授权许可】

Unknown