Epigenetic Alterations in Pediatric Sleep Apnea

International Journal of Molecular Sciences

Matthew Wyatt Kay¹  Emily Catherine Cheung¹  Kathryn Jaques Schunke¹ 

[1] Department of Biomedical Engineering, George Washington University, 800 22nd Street NW, Washington, DC 20052, USA;

关键词: epigenetic mechanisms of disease;    fetal programming;    obstructive sleep apnea;    DNA methylation;    histone modifications;    chronic disease;   

DOI  :  10.3390/ijms22179523

来源: DOAJ

【 摘 要 】

Pediatric obstructive sleep apnea has significant negative effects on health and behavior in childhood including depression, failure to thrive, neurocognitive impairment, and behavioral issues. It is strongly associated with an increased risk for chronic adult disease such as obesity and diabetes, accelerated atherosclerosis, and endothelial dysfunction. Accumulating evidence suggests that adult-onset non-communicable diseases may originate from early life through a process by which an insult applied at a critical developmental window causes long-term effects on the structure or function of an organism. In recent years, there has been increased interest in the role of epigenetic mechanisms in the pathogenesis of adult disease susceptibility. Epigenetic mechanisms that influence adaptive variability include histone modifications, non-coding RNAs, and DNA methylation. This review will highlight what is currently known about the phenotypic associations of epigenetic modifications in pediatric obstructive sleep apnea and will emphasize the importance of epigenetic changes as both modulators of chronic disease and potential therapeutic targets.

【 授权许可】

Unknown