Five New Alkaloids from the Stem Bark ofDaphniphyllum macropodum

Molecules

Yunyang Lu¹  Wei Zhang¹  Kai Gao¹  Haifeng Tang¹  Xiaoyang Wang¹  Ning Ma¹ 

[1] Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China;

关键词: Daphniphyllum macropodum;    daphnicyclidins M and N;    calyciphyllines Q–S;    alkaloids;    cytotoxicity;   

DOI  :  10.3390/molecules19033055

来源: DOAJ

【 摘 要 】

Five new alkaloids, daphnicyclidins M and N (compounds 1 and 2) and calyciphyllines Q–S (compounds 3–5), along with four known ones, paxiphylline C (6), macropodumine B (7), macropodumine C (8) and daphnicyclidin A (9) were isolated from the stem bark of Daphniphyllum macropodum. Calyciphylline Q (3) is the first calyciphylline A derivative possessing a double bond between C-18 and C-19. Their structures and relative configurations were elucidated on the basis of spectroscopic methods, especially 2D NMR techniques. Compounds 1, 2, 8 and 9 exhibited cytotoxic activity against P-388 cells with IC50 values of 5.7, 6.5, 10.3 and 13.8 µM, respectively. Compounds 1 and 2 also showed cytotoxic activity against SGC-7901 cells with IC50 values of 22.4 and 25.6 µM.

【 授权许可】

Unknown