Gradients of functional connectivity in the mouse cortex reflect neocortical evolution

NeuroImage

Ling Yun Yeow¹  Francesca Mandino²  Joanes Grandjean²  Julia M. Huntenburg³ 

[1] Corresponding author.;Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, Singapore 138667, Singapore;Systems Neuroscience Lab, Champalimaud Research, Av. Brasília, 1400-038 Lisbon, Portugal;

关键词: Cortical gradient;    Dual origin;    Intrinsic functional organization;    Mouse cortex;    Resting-state functional connectivity;   

DOI  :  

来源: DOAJ

【 摘 要 】

Understanding cortical organization is a fundamental goal of neuroscience that requires comparisons across species and modalities. Large-scale connectivity gradients have recently been introduced as a data-driven representation of the intrinsic organization of the cortex. We studied resting-state functional connectivity gradients in the mouse cortex and found robust spatial patterns across four data sets. The principal gradient of functional connectivity shows a striking overlap with an axis of neocortical evolution from two primordial origins. Additional gradients reflect sensory specialization and aspects of a sensory-to-transmodal hierarchy, and are associated with transcriptomic features. While some of these gradients strongly resemble observations in the human cortex, the overall pattern in the mouse cortex emphasizes the specialization of sensory areas over a global functional hierarchy.

【 授权许可】

Unknown