Comparing Pathological Risk Factors for Dementia between Cognitively Normal Japanese and Americans

Brain Sciences

Chendi Cui¹  Akira Sekikawa¹  Lewis H. Kuller¹  Yuefang Chang²  Masafumi Ihara³  Chikage Kakuta³  Oscar L. Lopez⁴  Makoto Watanabe⁵  Yoshihiro Miyamoto⁵  Aya Higashiyama⁵  Yoshihiro Kokubo⁵  Victor L. Villemagne⁶  William E. Klunk⁶  Howard J. Aizenstein⁶  Tetsuya Fukuda⁷  Chester A. Mathis⁸  Zheming Yu⁸  Brian J. Lopresti⁸ 

[1] Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA;Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA;Department of Neurology, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan;Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA;Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan;Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA;Department of Radiology, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan;Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA;

关键词: neuroimaging;    biomarker;    Japanese;    amyloid PET imaging;    magnetic resonance imaging;   

DOI  :  10.3390/brainsci11091180

来源: DOAJ

【 摘 要 】

The Alzheimer’s Disease Neuroimaging Initiative showed that Japanese had significantly lower brain Aβ burden than Americans among a cognitively normal population. This cross-sectional study aimed to compare vascular disease burden, Aβ burden, and neurodegeneration between cognitively normal elderly Japanese and Americans. Japanese and American participants were matched for age (±4-year-old), sex, and Apolipoprotein E (APOE) genotype. Brain vascular disease burden and brain Aβ burden were measured using white matter lesions (WMLs) and ¹¹C-labeled Pittsburgh Compound B (PiB) retention, respectively. Neurodegeneration was measured using hippocampal volumes and cortical thickness. A total of 95 Japanese and 95 Americans were recruited (50.5% men, mean age = 82). Compared to Americans, Japanese participants had larger WMLs, and a similar global Aβ standardized uptake value ratio (SUVR), cortical thickness and hippocampal volumes. Japanese had significantly lower regional Aβ SUVR in the anterior ventral striatum, posterior cingulate cortex, and precuneus. Cognitively normal elderly Japanese and Americans had different profiles regarding vascular disease and Aβ burden. This suggests that multiple risk factors are likely to be involved in the development of dementia. Additionally, Japanese might have a lower risk of dementia due to lower Aβ burden than Americans. Longitudinal follow-up of these cohorts is warranted to ascertain the predictive accuracy of these findings.

【 授权许可】

Unknown