COMPARATIVE ANTICONVULSANT AND ANTIHYPOXIC EFFECTS OF ASTROKS AND MEXIDOL IN INJECTABLE FORMAND 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE SUCCINATE SUBSTANCE

Эпилепсия и пароксизмальные состояния

S. A. Litvinova¹  I. O. Gaidukov¹  L. N. Nerobkova¹  T. A. Voronina¹  G. G. Avakyan²  G. N. Avakyan² 

[1] Institute of Pharmacology named V. V. Zakusov, Moscow;The Russian National Research Medical University named after N. I. Pirogov of the Ministry of Health of the Russian Federation, Moscow;

关键词: epilepsy;    primary generalized seizures;    mes;    pentylenetetrazole;    hypoxia;    mexidol.;   

DOI  :  10.17749/2077-8333.2016.8.1.075-082

来源: DOAJ

【 摘 要 】

The purpose of this study was to examine in experiment anticonvulsant and antihypoxic action of 2-ethyl-6-methyl-3-hydroxypyridine succinate medications — Astroks in injectable form (vial of 100 mg in 2 ml) compared with Mexidol injectable form (vial of 100 mg in 2 ml) and the substance 2-ethyl-6- methyl-3-hydroxypyridine succinate (EMHPS). Materials and methods. Simulation of primary generalized eizures was performed using the maximal electroshock (MES) and pentylenetetrazole injection. Antihypoxic effects of drugs was studied on the model of normobaric hypoxia with hypercapnia.Results: it was found that astroks injection at a dose of 200 mg/kg has a similar antihypoxic and anticonvulsant efficacy with EMHPS substance. Compared to injectable form of Meksidol astroks has similar efficacy in the test of antagonism with MES. Astroks exceeds the effect of Mexidol in the test of antagonism with pentylenetetrazole and has more severe antihypoxic action.Conclusion. Аstroks injectable has pronounced antihypoxic and anticonvulsant action in the experiment which have some advantages over injectable Meksidol.

【 授权许可】

Unknown