Footprints of microRNAs in Cancer Biology

Biomedicines

Emmanuel Jairaj Moses¹  Yaashini Rajasegaran¹  Mot Yee Yik¹  Adam Azlan¹  Khor Kang Zi¹  Narazah Mohd Yusoff¹  Aliaa Arina Rosli¹ 

[1] Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Kepala Batas 13200, Pulau Pinang, Malaysia;

关键词: microRNA (miRNA);    cancer biology;    gene regulation;    biomarkers;    therapeutic targets;   

DOI  :  10.3390/biomedicines9101494

来源: DOAJ

【 摘 要 】

MicroRNAs (miRNAs) are short non-coding RNAs involved in post-transcriptional gene regulation. Over the past years, various studies have demonstrated the role of aberrant miRNA expression in the onset of cancer. The mechanisms by which miRNA exerts its cancer-promoting or inhibitory effects are apparent through the various cancer hallmarks, which include selective proliferative advantage, altered stress response, vascularization, invasion and metastasis, metabolic rewiring, the tumor microenvironment and immune modulation; therefore, this review aims to highlight the association between miRNAs and the various cancer hallmarks by dissecting the mechanisms of miRNA regulation in each hallmark separately. It is hoped that the information presented herein will provide further insights regarding the role of cancer and serve as a guideline to evaluate the potential of microRNAs to be utilized as biomarkers and therapeutic targets on a larger scale in cancer research.

【 授权许可】

Unknown